![]() The present work is a cross-sectional epidemiological study based on the ACR established by Vet-OncoNet, in Portugal, and intends to compare tumor occurrence in dogs and cats. Ī study comparing the occurrence of tumor topographies and morphologies in cats and dogs can provide an important insight to similarities and differences in tumor occurrence, contributing to generate evidence and hypothesis to support and guide clinical and comparative research questions. The system includes the collection, treatment and reporting of data on tumors in companion animals to produce scientific evidence, that contributes to improve the knowledge in comparative oncology. Īware of its importance, Vet-OncoNet, the Veterinary Oncology Network has, included in its mission, the construction and maintenance of an Animal Cancer Registry (ACR) representative of Portuguese reality. Animal cancer data bases are also essential tools for cancer prevention and control in animals and humans. This important epidemiologic tool makes it possible to generate a hypothesis that enables the design of more precise analytic studies to identify causal associations between exposures and cancer risks. ![]() Only with an accurate animal cancer surveillance it is possible to produce important scientific evidence for the potential translational key role of companion animals in comparative studies with humans. Feline oral squamous cell carcinoma (SCC), which shares both clinical and molecular features with human head and neck cancer, and feline mammary tumors, sharing the ‘triple-negative’ phenotype with breast cancer in humans offer an enriched population model for evaluating new potential targets, treatments and environmental risk factors for cancer research. ĭomestic cats offer the same potential as dogs as a model, and may be even a better fit for some specific type of tumors, although they are not so often utilized to the same degree as dogs in the One Medicine approach to cancer. From a histological perspective, numerous cancer types, e.g., osteosarcomas, melanomas, non-Hodgkin lymphomas, bladder cancer, and mammary carcinomas are quite similar in dogs and humans. ĭogs are considered a useful, attractive, and complementary model of human cancer as sharing human physical, chemical environments, and approximately “650 Mb of ancestral genetic sequence”. Natural occurring diseases in companion animals, like cancer, are often similar and sometimes identical to human diseases, in terms of etiology, progression and treatment response. This study is the first outcome of continuous animal cancer registration studies in Portugal.Ĭompanion animals live in more than 88 million households in Europe (38% of all) with around 90 million dogs and 110 million cats. Females have greater odds only in the mammary gland, with males having greater odds in six of twelve topographies. While cats are overrepresented in fibrosarcomas, lymphomas (T and B-cell), in malignant mammary tumors, and squamous cell carcinoma (SCC). Regarding morphologies, dogs are overrepresented in mast cell tumors (MCT), melanomas, and hemangiosarcomas. ![]() The multivariate topography group analysis shows a distinct pattern between the two species: dogs have higher odds of cancer in the genito-urinary system, spleen, soft tissue tumors and skin, while cats show higher odds for tumors in the eyes, digestive organs, nasal cavity, lymph nodes, bones and mammary glands. In comparison, cats have a general one-year right advance in the mean age of cancer diagnosis compared to dogs. With 9079 registries, regarding 20, 81% ( n = 7355) belonged to dogs. The present work aims to describe, analyze, and compare frequencies and associations of tumors in dogs and cats based on the Animal Cancer Registry created by Vet-OncoNet. The animal cancer burden is essential for the translational value of companion animals in comparative oncology.
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